Comparative Assessment of Serum Lipid Profile and Uric Acid between Pregnant Normotensive and Hypertensive Women in Port Harcourt

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Published: 2022-12-30

Page: 348- 353


Tamuno-Opubo, Abiye *

Department of Human Physiology, College of Medical Sciences, Rivers State University, Rivers State, Nigeria.

Stanley, Rosemary Oluchi

Department of Internal Medicine, University of Port Harcourt Teaching Hospital, Rivers State, Nigeria.

Bademosi Adetomi

Department of Community Medicine, College of Medical Sciences, Rivers State University, Rivers State, Nigeria.

Austin-Asomeji, Iyingiala

Department of Community Medicine, College of Medical Sciences, Rivers State University, Rivers State, Nigeria.

George Abiye

Department of Anaesthesiology, College of Medical Sciences, Rivers State University, Rivers State, Nigeria.

Obiandu Chibuike

Department of Human Physiology, College of Medical Sciences, Rivers State University, Rivers State, Nigeria.

Orabere, Josephine Tamunomiebaka

Department of Human Physiology, College of Medical Sciences, Rivers State University, Rivers State, Nigeria.

*Author to whom correspondence should be addressed.


Abstract

Aim: The aim of this study was to compare the serum lipid profile and uric acid between normotensive and hypertensive pregnant women.

Study Design: Comparative Cohort study.

Study Area and Duration: Port Harcourt, Nigeria. January – July, 2022.

Methods: A cross-sectional study was carried out among 50 hypertensive and 50 normotensive pregnant women from RSUTH, PH. Blood pressure was measured. Demographic data such as age, parity gestational age was collected. Fasting blood samples were collected and analyzed for total cholesterol, triglyceride, low-density lipoprotein (LDL), high-density lipoprotein (HDL) and uric acid.

Results: The study showed a significantly higher (P< 0.05) level of TC and LDL among the hypertensive group compared to the normotensive group. There was no statistically significant difference in the uric acid levels between the subcategories of the study group.

Conclusion: From the results of the present study, it was concluded that PIH is associated with increased levels of TC and LDL. This association may be important in understanding the pathologic processes of the disease and in developing strategies for its prevention and early diagnosis.

Keywords: Pregnancy, normotensive, hypertensive, lipid profile, uric acid


How to Cite

Abiye, Tamuno-Opubo, Stanley, Rosemary Oluchi, Bademosi Adetomi, Austin-Asomeji, Iyingiala, George Abiye, Obiandu Chibuike, and Orabere, Josephine Tamunomiebaka. 2022. “Comparative Assessment of Serum Lipid Profile and Uric Acid Between Pregnant Normotensive and Hypertensive Women in Port Harcourt”. International Journal of Research and Reports in Gynaecology 5 (1):348-53. https://journalijrrgy.com/index.php/IJRRGY/article/view/81.

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References

Melchior JT, Swertfeger DK, Morris J, et al. Pregnancy is accompanied by larger high density lipoprotein particles and compositionally distinct subspecies. J Lipid Res; 62. Epub Ahead of Print 1; 2021. DOI: 10.1016/J.JLR.2021.100107

Tinawi M. Hypertension in Pregnancy. Hypertension. 2020;3:596–602.

Jena M, Mishra S, Jena S, et al. Pregnancy induced hypertension & pre eclampsia : Pathophysiology & recent management trends : A review. 2016;5:326–334.

Waage CW, Mdala I, Stigum H, et al. Lipid and lipoprotein concentrations during pregnancy and associations with ethnicity. BMC Pregnancy Childbirth. 2022;22: 1–12.

Sridhara SK. A comparative analysis of serum lipid profile between normotensive and hypertensive pregnant women. Int J Reprod Contraception, Obstet Gynecol. 2019;8:2060.

Fatima SA, Latha JM, Vani N, et al. A comparative study of serum lipids and lipoprotein- A levels of women with pregnancy induced hypertension (PIH) and normotensive pregnant women. Int J Clin Biochem Res. 2021;7:488–496.

Avidime AR, Tella MA, Hadiza G, et al. A comparative Study of Serum Lipid Levels in Pre- Eclamptic and Normotensive Pregnant Women in a Tertiary Hospital, Northwest Nigeria. Biomed J Sci Tech Res; 3. Epub Ahead of Print; 2018. DOI: 10.26717/bjstr.2018.03.000845

Schmella MJ, Clifton RG, Althouse AD, et al. Uric acid determination in gestational hypertension. Reprod Sci. 2015;22:1212–1219.

Lam C, Lim K, Kang D, et al. Uric Acid and Preeclampsia. 2005; 56–60.

Bellomo G, Venanzi S, Saronio P, et al. Prognostic significance of serum uric acid in women with gestational hypertension. Hypertension. 2011;58:704–708.

Diwan J, Shah C, Dixit R, et al. Original article A Comparative Study of Serum Uric Acid Level in Normal Pregnancy , and Pregnancy Induced Hypertension. 2011;1: 39–42.

Akahori Y, Masuyama H, Hiramatsu Y. The correlation of maternal uric acid concentration with small-for-gestational-age fetuses in normotensive pregnant women. Gynecol Obstet Invest 2012;73: 162–167.

Irwinda R, Surya R, Nembo LF. Impact of pregnancy-induced hypertension on fetal growth. Med J Indones. 2016;25:104–111.

Attali E, Yogev Y. The impact of advanced maternal age on pregnancy outcome. Best Pract Res Clin Obstet Gynaecol. 2021;70:2–9.

Parikh AR, van Seventer EE, Siravegna G, et al. Minimal Residual Disease Detection using a Plasma-only Circulating Tumor DNA Assay in Patients with Colorectal Cancer. Clin Cancer Res. 2021;27:OF1–OF9.

Grimes SB, Wild R. Effect of Pregnancy on Lipid Metabolism and Lipoprotein Levels. Endotext, Available:https://www.ncbi.nlm.nih.gov/books/NBK498654/ (2018, accessed 4 March 2023).

Hamed Khalil SS, ElShourbagy SH, Hamad SM, et al. Hyperuricemia as a Predictor of Perinatal Outcomes in Pregnancy Induced Hypertension. Gynecol Obstet Res - Open J. 2018;5:15–21.

Anjum R, Zahra N, Rehman K, et al. Comparative Analysis of Serum Lipid Profile between Normotensive and Hypertensive Pakistani Pregnant Women. J Mol Genet Med; 07. Epub Ahead of Print; 2013. DOI: 10.4172/1747-0862.1000064