Impact of Eliozu Port Harcourt Landfill Leachate on Some Reproductive Hormones in Female Wistar Rats

Main Article Content

Green, I. Kinikanwo
Oriji, K. Vadunume
Weleh, I. Ikechukwu

Abstract

Pollution of water sources by leachate and the toxicity that ensues have been reported globally. However, there is still need to evaluate its effects on reproductive hormones; considering the influence of environment on reproduction and the increasing number of infertility cases in the society. In this study therefore, the effect of landfill leachate at Eliozu in Port Harcourt Nigeria on some female reproductive hormones were evaluated using Wistar rats as experimental model. Twenty-five rats were grouped divided into five groups with five rats each. Group 1 served as control and received 1 ml of commercially bottled water, group 2 received 1ml of water from borehole about 1 km from the landfill; while groups 3, 4 and 5 received 1ml of 10%, 50% and 100% concentrations of leachate once daily for 30 consecutive days. All administrations were through oral gavage and animals were handled in line with guidelines for experimental animal care and handling. At the end of 30-days administrations, the animals were anaesthetized and about 4 ml of blood was collected through cardiac puncture; serum obtained was used to determine the serum concentrations of follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin, progesterone and estrogen. Results showed that leachate exposure at various concentrations caused a significant decrease in FSH, LH and prolactin p≤0.05; and a significant increase in progesterone and estrogen compared with the control group p≤0.05. This study therefore concludes that leachate could alter female reproductive hormones.

Keywords:
Prolactin, progesterone, estrogen, leachate, follicle stimulating hormone, luteinizing hormone.

Article Details

How to Cite
Kinikanwo, G. I., Vadunume, O. K., & Ikechukwu, W. I. (2020). Impact of Eliozu Port Harcourt Landfill Leachate on Some Reproductive Hormones in Female Wistar Rats. International Journal of Research and Reports in Gynaecology, 3(1), 20-24. Retrieved from https://journalijrrgy.com/index.php/IJRRGY/article/view/30103
Section
Original Research Article

References

Vincenzo Torretta, Navarro Ferronata, Ioannis A. Katsoyiannis, Anthanasia K. Tolkou, Michela Airoldi. Novel and conventional technologies for landfill leachates treatment. A Review. Sustainability. 2017;9(9):8-39.

Vaccari M, Torretta V, Collivignarelli C. Effect of improving environmental sustainability in developing countries by upgrading solid waste management techniques: A case study. Sustainability. 2012;4:2852–2861.

Guerrero LA, Maas G, Hogland W. Solid waste management challenges for cities in developing countries. Waste Management. 2013;33:220–232.

Chatham-Stephens K, Caravanos J, Ericson B, Landrigan P, Fuller R. The pediatric burden of disease from lead exposure at toxic waste sites in low and middle income countries. Environmental. Research. 2014;132:379–383.

Alam R, Chowdhury MAI, Hasan GMJ, Karanjit B, Shrestha LR. Generation, storage, collection and transportation of municipal solid waste–A case study in the city of Kathmandu capital of Nepal. Waste Management. 2008;28:1088–1097.

Al Sabbagh MK, Velis CA, Wilson DC, Cheeseman CR. Resource management performance in Bahrain: A systematic analysis of municipal waste management, secondary material flows and organiza-tional aspects. Waste Management. Research. 2012;30:813–824.

Ogbonna VA, Nwankwoala HO, Lawal O. Impacts of landfill on groundwater quality in Eligbolo-Eliozu, Obio/Akpor Local Government Area, Rivers State. Nigeria. African Journal of Basic and Applied Sciences. 2016;8(4):232-239.

Iyke I. Weleh, Owunari A. Georgewill Victor D. Dapper. Effect of Port Harcourt (Eliozu) landfill leachates on oxidative stress using oxidative stress markers in wistar rats. IOSR Journal of Environmental Science, Toxicology and Food Technology (IOSR-JESTFT). 2020;14(4):01-04.

Nwoke KU, Ezeh NP, Adienbo OM. Some occupations and their effects on hematological parameters of exposed individuals in Port Harcourt, Nigeria. International Journal of Science and Research Methodology. 2017;8(2):50-57.

Robert M Beme, Mathew N. Levy. Physiology (3rd edition). A mosby imprint of mosby year Book, Inc. 1993;897-899.

Muliari Muliari, Ilham Zulfahmi, Yusrizal Akmal, Ni Wayan Kurniani Karja, Chairun Nisa, Kizar Ahmed Sumon. Effects of palm oil mill effluent on reproductive hormone of female nile tilapia, Oreochromis niloticus (Linnaeus). Advances in animal and veterinary Sciences. 1758;11(7):1035-1041.

Zulfahmi I, Ridwan A, Djamar TFL. Perbahanstrktur histolog is insangdanikannila (Oreochromis niloticus Linnaeus 1758) yang terpaparmerkuri [Histological changes of liver and gill of Nile Tilapia (Oreochromis niloticus Linneus 1758) after mercury exposure]. Journal of Edukasidansains Biol. 2019;4(1):31-35.

Uotila M, Ruoslathi E, Envall E. Two-site sandwich enzyme immunoassay with monoclonal antibodies to human alpha fetoprotein. Journal of Immunology Method. 1981;42:11-15.

Tietz NW. Clinical guide to laboratory texts (3rd edition). W.B Saunders Company, Philadelphia. 1995;1-997.

Kumar S, Zaidi S, Gautam A, Dave L, Saiyed H. Semen quality and reproductive hormones among welders—A preliminary study. Environmental Health and preventive medicine. 2003;8:64-67.

Chikezie IC, Charles-Davies MA, Balogun AM, Okoli SU. Effects of endocrine disrupting heavy metals on pituitary and gonadal hormones in normal weight automachanics in Ibadan, Nigeria. Africa Journal of Biomedical Research. 2017; 20:20-35.

Anna Z. Pollack, Enrique F. Schisterman, Lynn R. Goldman, Sunni L. Mumford, Paul S. Albert, Robert L. Jean Wactawski-Wende. Cadmium, lead and mercury in relation to reproductive hormones and anovulation in premenopausal Women. Environmental Health Perspectives. 2011; 119(18):1156-1161.

Carol Winstel, Phyllis Callahan. Cadmium exposure inhibits the prolactin secretory response to thyrotrophin releasing hormone (TRH) in vitro. Toxicology Elsevier. 1992;74(1):9-17.

Maues LAL, Machi BM, Crespo-Lopez ME, Nascuitti LE, Picanco-Diniz DLW, Antunes-Rodrigues J, do Nascimento JLM. Methylmercury inhibits prolactin release in a cell line of pituitary origin. Brazilian Journal of Medicine and Biological Research. 2015;48(8):691–696.

Santoro N, Brown JR, Adel T, Skurnick JH. Characteristization of reproductive hormonal dynamics in the perimenopause. Journal of Clinical Endocrinological Metabolism. 1996;81(4):1495-1501.