Effect of Chronic Exposure to Gas Flaring on Sex Hormones and Some Antioxidant Parameters of Men from Ebocha, Niger Delta Area of Nigeria

Main Article Content

I. P. Mokelu
G. O. C. Onyeze
L. A. Nwaogu
C. U. Igwe

Abstract

Aim: The effect of pollution due to gas flaring on men native to Ebocha, in the Niger Delta Area of Nigeria was investigated.

Materials and Methods: Blood specimens from twenty approximately healthy men from Ebocha community within the age groups 30-34, 35-39, 40-44, 45-49, 50-54 years were screened. Control blood specimens were obtained from twenty approximately healthy men from Uzi, Owerri (a location with no history of petroleum hydrocarbon pollution) with the same age bracket. Standard analytical procedures were used to determine the concentrations of male sex hormones; testosterone, luteinizing hormone (LH) and follicle stimulating hormone (FSH). Some antioxidant parameters; glutathione and ascorbic acid (vitamin C) were also determined. The activity of lactate dehydrogenase (LDH) was also assayed.

Results: Results obtained revealed that there was a significant (p < 0.05) decrease in testosterone concentrations of men from Ebocha within the age groups of 35-39, 45-49 and 50-54 in contrast to those within the age groups of 30-34 and 40-44 when compared to the control. There was a significant (p < 0.05) increase in the concentration of  LH of only men from Ebocha within the age group 45-49 when compared to those from Owerri. There was no significant (p < 0.05) difference in the concentration of FSH of men within the age groups from both sites. However, there was a significant (p < 0.05) decrease in the concentrations of GSH for all age groups in men from Ebocha when compared to those from the control sites. The same trend was observed for ascorbic acid concentrations in men from Ebocha for all the age groups from 30-54 years old. There was a significant (p < 0.05) increase in LDH activity of men from Ebocha among all the age groups when compared to those from Owerri.

Conclusion: These findings show that testosterone, glutathione, ascorbic acid concentrations and lactate dehydrogenase activity in the blood specimens of men from Ebocha were affected and it is possibly due to the chronic exposure to gas flaring in the environment.

Keywords:
Antioxidants, chronic exposure, gas flaring, Niger Delta, sex hormones.

Article Details

How to Cite
Mokelu, I. P., Onyeze, G. O. C., Nwaogu, L. A., & Igwe, C. U. (2020). Effect of Chronic Exposure to Gas Flaring on Sex Hormones and Some Antioxidant Parameters of Men from Ebocha, Niger Delta Area of Nigeria. International Journal of Research and Reports in Gynaecology, 3(1), 9-19. Retrieved from https://journalijrrgy.com/index.php/IJRRGY/article/view/30102
Section
Original Research Article

References

Ahmadu J, Egbodion J. Effect of oil spillage on cassava production in Niger Delta Region of Nigeria. American Journal of Experimental Agriculture. 2013;3:914-926.

Ajugwo AO. Negative Effects of Gas Flaring: The Nigerian Experience. Journal of Environment Pollution Human Health. 2013;1(1):6-8.

Aghalino SO. Petroleum Exploration and the Agitation for Compensation by Oil Mineral Producing Communities in Nigeria. J. Environ. Policy Issues. 2000;1:2.

Ashton N, Arnott S, Douglas O. The human ecosystem of the Niger Delta. An Era Handbook. Lagos: Environmental Rights Action; 1999.

Nwaogu LA, Onyeze GOC. Environmental impact of gas flaring on Ebocha-Egbema, Niger Delta. Nigerian Journal of Bio-chemistry and Molecular Biology. 2010; 25(2):26-31.

Ukoli MK. Environmental factors in the management of the oil and gas industry in Nigeria; 2005.
Available:http://www.cenbank.org (Retrieved May 10, 2013).

Ademoroti MA. Environmental chemistry and toxicology. Foludex Press Limited, Ibadan. 1996;3:121-125.

Holdgate MW, White GF. International Council of Scientific Unions, Scientific Committee on Problems of the Environ-ment. Environmental issues. London; New York: Wiley; 1977.

Ikoro NJ. The socio-economic implications of gas flaring in Nigeria. Du-France communications, Yenagoa, Bayelsa State, Nigeria. 2003; 1-6.

Nwaogu LA, Onyeze CE, Alisi CS, Ijeh II, Onyeze GOC. Petroleum hydrocarbon-induced changes in tissues of native fowl (Gallus domesticus) following chronic exposure. Nigerian Journal of Biochemistry and Molecular Biology. 2008;23(1):42-46.

Nwaogu LA, Onyeze GOC. Effect of chronic exposure to petroleum hydrocarbon pollution on oxidative stress parameters and histology of liver tissues of native fowl (Gallus domesticus). International Journal of Biochemistry Research & Review. 2014;4(3):233-242.

Nnorom LC, Nwaogu LA, Onyeze GOC. Petroleum hydrocarbon-induced changes in juice of Citrus sinesis following chronic exposure. International Journal of Biochemistry Research and Review. 2015; 5(1):56-62.

Reitman S, Frankel S. A colorimetric method for determination of serum glutamate oxaloacetate and glutamic pyruvate transaminase. American Journal of Clinical Pathology. 1957;28:56-58.

Airaodion AI, Akinmolayan JD, Ogbuagu EO, Esonu CE, Ogbuagu U. Preventive and therapeutic activities of methanolic extract of Talinum triangulare leaves against ethanol-induced oxidative stress in Wistar rats. International Journal of Bio-Science and Bio-Technology. 2019; 11(7):85-96.

Benderitter M, Maupoli V, Vergely C, Dalloz F, Briot F, Rochette L. Studies by electron paramagnetic resonance of the importance of iron in the hydroxyl scavenging properties of ascorbic acid in plasma: Effects of iron chelators. Fundamental of Clinical Pharmacology. 1998;12:510–516.

Tietz NW. Clinical guide to laboratory Tests. 3rd edition. Philadelphia, W.A Saunders Co; 1995.

Kosasa TS. Measurnent of human luteinizing hormone. Journal of Reproductive Medicine. 1981;26:201-206.

Marshall JC. Clinic in Endorinol Metab. 1975;4:545.

Owoade AO, Adetutu A, Airaodion AI, Ogundipe OO. Toxicological assessment of the methanolic leaf extract of Bridelia ferrugelia. The Journal of Phyto-pharmacology. 2018;7(5):419-424.

Airaodion AI, Ogbuagu U, Ekenjoku JA, Ogbuagu EO, Airaodion EO, Okoroukwu VN. Hepato-protective efficiency of ethanol leaf extract of Moringa oleifera against hydrocarbon exposure. International Journal of Advances in Herbal and Alternative Medicine. 2019;03(01):32- 41.

Airaodion AI, Ogbuagu EO, Ogbuagu U, Adeniji AR, Agunbiade AP, Airaodion EO. Hepatoprotective effect of Parkia biglobosa on acute ethanol-induced oxidative stress in Wistar rats. International Research Journal of Gastroenterology and Hepatology. 2019;2(1):1-11.

Airaodion AI, Ogbuagu EO, Ewa O, Ogbuagu U, Awosanya OO, Adekale OA. Ameliorative efficacy of phytochemical content of Corchorus olitorius leaves against acute ethanol-induced oxidative stress in Wistar rats. Asian Journal of Biochemistry, Genetics and Molecular Biology. 2019;7(6):1-9.

Ogbuagu EO, Airaodion AI, Ogbuagu U, Airaodion EO. Prophylactic propensity of methanolic extract of Vernonia amygdalina leaves against acute ethanol-induced oxidative stress in Wistar rats. International Journal of Bio-Science and Bio-Technology. 2019;11(7):37-46.

Mehdi M, Menon MKC, Seyoum N, Bekele M, Tigeneh W, Seifu D. Blood and tissues enzymic activities of GDH and LDH index of glutathione and oxidative stress among breast cancer patients attending referral hospitals of Addis Abba, Ethiopia hospital-based comparative cross-sectional study. 2018;2:123-142

Airaodion AI, Airaodion EO, Ewa O, Ogbuagu EO, Ogbuagu U. Nutritional and anti–nutritional evaluation of garri processed by traditional and instant mechanical methods. Asian Food Science Journal. 2019;9(4):1-13.

Fiaschi AI, Cozzolino A, Ruggiero G, Giorgi G. Glutathione, ascorbic acid and antioxidant enzymes in the tumor tissues and blood of patients with oral carcinoma. European Review for Medical and pharmacological Sciences. 2005;9:361-367.

Grandjean P, Grønlund C, Kjær IM, Jensen TK, Sørensen N, Andersson AM. Reproductive hormone profile and pubertal development in 14-year-old boys prenatally exposed to polychlorinated biphenyls. Reprod Toxicol. 2012;34(4): 498-503.

Dixon XL. Assessment of chemicals affecting the male reproductive system. Arch. Toxicol. Suppl, T. 1984;118-127.

Darbe PD. Overview of air pollution and endocrine disorders. International Journal of General Medicine. 2018;11:191-207.

Airaodion AI, Ngwogu AC, Ekenjoku JA, Ngwogu KO. Effect of common household insecticides used in Nigeria on rat male reproductive hormones. International Journal of Research and Reports in Gynaecology. 2019;2(1):1-8.

Darbandi M, Darbandi GE, Agarwal A, Sengupta P, Durairajanayagam D, Henkel R, Sadeghi MR. Effect of reactive oxygen species on sex hormones. Reproductive Biology and Endocrinology. 2018;16:87.

Manna PR, Tena-Sempere M, Huhtaniemi IT. Molecular mechanisms of thyroid hormone-stimulated steroidogenesis in mouse Leydig tumor cells involvement of the steroidogenic acute regulatory (StAR) protein. J Biol Chem. 1999;274(9):5909–5918.