Immunohistochemical Study of Estrogen and Progesterone Receptors and the Proliferation Marker Ki-67 in Abdominal Wall Endometriosis
Published: 2021-03-16
Page: 10-17
Issue: 2021 - Volume 4 [Issue 1]
Francisco das Chagas Medeiros
Department of Maternal and Child Health, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil.
Manoel Oliveira Filho
Department of Maternal and Child Health, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil.
José Eleutério Junior
*
Department of Maternal and Child Health, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil.
Angelina da Silva Medeiros
Medicine School, Fortaleza University, Fortaleza, Brazil.
*Author to whom correspondence should be addressed.
Abstract
Introduction: The scar from pelvic surgery in the abdominal wall can be a site of endometriotic implants in 0.03 to 1% of patients. This study aims to evaluate the immunohistochemical expression of the estrogen receptor (ER), progesterone receptor (PR), and cell proliferation marker Ki-67 in patients with abdominal wall endometriosis.
Materials and Methods: We investigated seven women with abdominal wall endometriosis who underwent surgery to remove a lesion at the Assis Chateaubriand Maternity, Fortaleza, Brazil. From tissue blocks, histological sections were subjected to immunohistochemistry to identify ER, PR, and Ki-67. For statistical significance, an unpaired t-test was applied with a 95% confidence interval.
Results: The mean patient age was 30.4 ± 1.13 years. ER expression in the epithelium and stroma had a mean score of 33.45 and 17.14, respectively, and the difference was not significant. PR had a mean epithelial score of 175.71 and a mean stromal score of 72.29, significantly different (p = 0.0339). Ki-67 had epithelial and stromal scores of 14.14 and 12.14, respectively, which were not significantly different.
Conclusions: Abdominal wall endometriosis presents ER and variable PR expression in the epithelium and stroma. The Ki-67 marker demonstrated a reduced proliferation index.
Keywords: Endometriosis, abdominal wall, estrogen receptor, progesterone receptor, Ki-67.