International Journal of Research and Reports in Gynaecology

High-risk pregnancies present a significant challenge in obstetric care due to their association with adverse maternal outcomes, including increased morbidity and mortality. This systematic review evaluates the efficacy of various intervention strategies employed in high-risk pregnancies in the United States between 2014 and 2023. A comprehensive search of four major medical databases including PubMed, Cochrane Library, Scopus, and Embase, was conducted to identify studies focusing on pharmacological, surgical, lifestyle, and technological interventions. 85 studies were selected based on inclusion criteria, and their outcomes were synthesized both qualitatively and quantitatively. Pharmacological interventions, such as antihypertensives for preeclampsia and insulin for gestational diabetes, were found to significantly reduce maternal complications. Surgical interventions, particularly cesarean delivery, were critical in managing structural complications but associated with higher morbidity. Lifestyle interventions, including diet, exercise, and prenatal education, showed efficacy in managing gestational diabetes and reducing preterm birth rates. Technological advances like telemedicine and fetal monitoring demonstrated improved access to care and maternal outcomes, particularly in underserved populations. The review highlights the importance of personalized, condition-specific intervention strategies and underscores the need for multidisciplinary approaches to high-risk pregnancy management. Socioeconomic and racial disparities in maternal outcomes remain a concern, emphasizing the need for targeted public health initiatives.